Publikationsliste
Ausgewählte Publikationen
2026
Dysregulated sphingolipid metabolismdrives pancreatic carcinogenesis through plasma membrane Kras enrichment
Ahmed Alnatsha, Jianying Xu, Tahib Habshi, Qi Li, Klea Rickú, Prince Allawadhi, Didem Saka, Ruoxan Dai, Yuxing Xue, Hang Nguyen, Helena Stadler, Theresa Weltermann, Quan Zhou, Nicole Schreiner, Yonggan Xue, Victoria Rittinghausen, Steffen Ormanns, Fredrick Klauschen, Danmei Zhang, Stefan Böck, Martin Benoit, Najib Ben Khaled, Shibojyoti Lahiri, Axel Imhof, Andreas Klingl, Anjali Jaiswal, Girija P Sahoo, Ivonne Regel, Sebastian Mueller, Rupert Öllinger, Roland Rad, Claus Belka, Tanja Bange, Kirsten Lauber, Julia Mayerle, Ujjwal M Mahajan Gut. https://pubmed.ncbi.nlm.nih.gov/42399085/
Depth of neutrophil mobilization stratifies survival in ST-elevation myocardial infarction
Mathis Richter, Jessica von Göwels, Maximilian Fähndrich, Christian Lipgens Fernandez, Katharina Grohn, Marius Welzel, Dennis Schwarz, Alexander Lang, Amin Polzin, Sara Reinartz Groba, Luca Farinola, Susmita Ghosh, Jan-Niklas Heming, Hanna Aleth, Anastassia Akhalkatsi, Kian Marjani, Nicole Rübsamen, Tobias Radecke, Frank Rosenbauer, Albert Sickmann, André Karch, Alexander Zarbock, Jens Minnerup, Jürgen Sindermann, Alexander Bender, Jan Rossaint, Steffen Ormanns, Matthias Gunzer, Mariano Malamud, Rainer Kaiser, Kami Pekayvaz, Dominik Heider, Holger Reinecke, Lena Makowski, Christian Jung, Carlos Silvestre-Roig, Malte Kelm , Norbert Gerdes, Raphael Chevre, Stefan A Lange, Oliver Soehnlein Nat Cardiovasc Res. https://pubmed.ncbi.nlm.nih.gov/42399420/
TROP2 targeting reveals therapy-driven cell state dynamics in colorectal cancer
Nuria Vaquero-Siguero, Nikolaos Georgakopoulos, Maria C. Puschhof, Ioannis Chiotakakos, Jasmin Meier, Sigrid K. Fey, Gabriele Diamante, Manuel Mastel, Aitana Guiseris-Martinez, Guillaume Belthier, Nikolai Schleußner, Julia Volk, Carolin Artmann, Bryce Lim, Ronald Koschny, Cyrill Wehling, Kyanna S. Ouyang, Michael Günther, Solveig Kuss, Paula Hoffmeister, Moritz Mall, Jens Neumann, Steffen Ormanns, Martin Schneider, Thomas Schmidt, Jens Puschhof, Andreas Trumpp, Jacco van Rheenen, Julio Saez-Rodriguez, Bruno C. Köhler & Rene Jackstadt Nature. https://pubmed.ncbi.nlm.nih.gov/42386981/
Targeting HER2 in urothelial carcinoma: from pathway inhibition to antibody–drug conjugates
Hamed Wafa, Nils C.H. van Creij, Michael Guenther*, Maxim Noeparast, Jose Daniel Subiela, Angelika Terbuch, Dora Niedersuess-Beke, Zoran Culig, Steffen Ormanns**, Renate Pichler Cancer Treatment Reviews.https://www.cancertreatmentreviews.com/article/S0305-7372(26)00087-3/fulltext
*joint first author, **joint last author
Neutrophil-Driven Trogocytosis in PDAC Liver Metastasis Restrains Immunosuppressive Macrophage Polarization and Limits Metastatic Progression
Larissa Belz, Dominic van den Heuvel, Badr Kilani, Alejandro Martinez-Navarro, Anastassia Akhalkatsi, Markus Joppich, Yinfeng Zhu, Qiongjie Ding, Jinlong Wan, Julia Stermann, Julia Winterhalter, Denise Messerer, Anna Titova, Sanjana Balaji, Santoshi Giri, Luke Eivers, Sebastian Widholz, Stefanie Bärthel, Elisabeth Raatz, Dieter Saur, Kirsten Lauber, Georg Beyer, Julia Mayerle, Steffen Ormanns, Michael Günther, Steffen Massberg, Hellen Ishikawa-Ankerhold, Konstantin Stark Gastroenterology. https://pubmed.ncbi.nlm.nih.gov/42102979/
IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases
Christina Plattner, Gregor Sturm, Anja A. Kühl, Raja Atreya, Sandro Carollo, Raphael Gronauer, Dietmar Rieder, Michael Günther, Steffen Ormanns, Claudia Manzl, Stefan Wirtz, Asier Rabasco Meneghetti, Ahmed N. Hegazy, Jay V. Patankar, Zunamys I. Carrero, TRR241 IBDome Consortium, Markus F. Neurath, Jakob Nikolas Kather, Christoph Becker, Britta Siegmund, Zlatko Trajanoski Gastroenterology. https://pubmed.ncbi.nlm.nih.gov/40386420/
Multi‐omic profiling defines three distinct molecular subtypes of urothelial carcinoma with implications for precision therapy
Nils C. H. van Creij, Piotr Tymoszuk, Florian Handle, Andreas Seeber, Teresa Sellemond, Agnieszka Martowicz, Eva Comperat, Hamed Wafa, Steffen Ormanns, Michael Günther, Walther Parson, Maxim Noeparast, Frédéric R. Santer, José Daniel Subiela, Petros Grivas, Roger Li, Zoran Culig, Renate Pichler Clin Transl Med. https://pubmed.ncbi.nlm.nih.gov/41804750/
Unveiling sex differences in pancreatic ductal adenocarcinoma: Current evidence and future directions
Rauschenberg S, Orgler-Gasche E, Karakas Zeybek D, Regel I, Löhr JM, Öhlund D, Günther M*, Aguilera Munoz L
Int J Oncol. https://doi.org/10.3892/ijo.2026.5848
*joint last author
Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer
Valentin Marteau, Niloofar Nemati*, Kristina Handler, Deeksha Raju, Alexander Kirchmair, Dietmar Rieder, Erika Kvalem Soto, Georgios Fotakis, Glenn De Lange, Sandro Carollo, Nina Boeck, Alessia Rossi, Sophia Daum, Alexandra Scheiber, Arno Amann, Andreas Seeber, Elisabeth Gasser, Steffen Ormanns, Michael Günther, …, Zlatko Trajanoski
Cancer Cell. https://doi.org/10.1016/j.ccell.2025.12.003
*joint first author
2025
Diagnostic approaches to cancer of unknown primary—the pathologist’s perspective
Guenther M, Brunner-Véber A, Ormanns S
Memo – Magazine of European Medical Oncology. https://link.springer.com/article/10.1007/s12254-025-01093-w
Ex vivo modelling of human colorectal cancer liver metastasis by normothermic machine perfusion
Manuel Trebo, Thomas Maurer, Felix J Krendl, Stefan Salcher, Agnieszka Martowicz, Theresa Hautz, Sieghart Sopper, Arno Amann, Benno Cardini, Lukas H Poelsler, Anna Mair, Julia Hofmann, Andras T Meszaros, Martin Hermann, Michael Günther, Steffen Ormanns, Zlatko Trajanoski, Stefan Schneeberger, Dominik Wolf, Rupert Oberhuber, Andreas Pircher
Mol Cancer. https://doi.org/10.1186/s12943-025-02430-7
Intratumoral bacterial abundance confers poor response to adjuvant gemcitabine in resected pancreatic cancer patients which is mitigated by postoperative antibiotics
Guenther M*, Surendran SA, Hauer N, Fahrenschon F, Arslan MD, Ormanns S.
Br J Cancer. https://doi.org/10.1038/s41416-025-03078-2
*joint first author
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer
Gilles Rademaker, Grace A Hernandez, Yurim Seo, Sumena Dahal, Lisa Miller-Phillips, Alexander L Li, Xianlu Laura Peng, Changfei Luan, Longhui Qiu, Maude A Liegeois, Bruce Wang, Kwun W Wen, Grace E Kim, Eric A Collisson, Stephan F Kruger, Stefan Boeck, Steffen Ormanns, Michael Guenther, Volker Heineman, Michael Haas, Mark R Looney, Jen Jen Yeh, Roberto Zoncu, Rushika M Perera
Nature. https://doi.org/10.1038/s41586-025-09017-8
FGFR1/3 Signaling as an Achilles‘ Heel of Phenotypic Diversity in Urothelial Carcinoma
Renate Pichler, Nils C H van Creij, Laura S Mertens, Francesco Del Giudice, Florestan Koll, Francesco Soria, José Daniel Subiela, Henning Plage, Piotr Tymoszuk, Roman Mayr, Gerald Klinglmair, Andreas Seeber, Martin Pichler, Michael Günther, Steffen Ormanns, Eva Compérat, Roger Li, Marco Moschini, Benjamin Pradére
Eur Urol Oncol. https://doi.org/10.1016/j.euo.2025.07.005
Multidimensional differences of right- and left-sided colorectal cancer and their impact on targeted therapies
Marwa Abdel Hamid, Lorenz M Pammer, Silvia Oberparleiter, Michael Günther, Arno Amann, Rebecca A Gruber, Anna Mair, Fabienne I Nocera, Steffen Ormanns, Kai Zimmer, Romana R Gerner, Florian Kocher, Samuel M Vorbach, Dominik Wolf, Jakob M Riedl, Florian Huemer, Andreas Seeber
NPJ Precis Oncol. https://doi.org/10.1038/s41698-025-00892-y
The Prognostic, Predictive and Clinicopathological Implications of KRT81/HNF1A- and GATA6-Based Transcriptional Subtyping in Pancreatic Cancer
Guenther M, Surendran SA, Steinke LM, Liou I, Palm MA, Heinemann V, Haas M, Boeck S, Ormanns S.
Biomolecules. https://doi.org/10.3390/biom15030426
2024
Prognostic and functional role of the nuclear export receptor 1 (XPO1) in gastrointestinal cancers: a potential novel target?
Viktorija Sokolova, Rebecca Gruber, Lorenz M Pammer, Florian Kocher, Eckhard Klieser, Arno Amann, Renate Pichler, Michael Günther, Steffen Ormanns, Daniel Neureiter, Andreas Seeber
Mol Biol Rep. https://doi.org/10.1007/s11033-024-10169-5
2023
TPX2 expression as a negative predictor of gemcitabine efficacy in pancreatic cancer
Guenther M, Surendran SA, Haas M, Heinemann V, von Bergwelt-Baildon M, Engel J, Werner J, Boeck S, Ormanns S.
Br J Cancer. https://doi.org/10.1038/s41416-023-02295-x
Immobility-associated thromboprotection is conserved across mammalian species from bear to human
Manuela Thienel, Johannes B Müller-Reif, Zhe Zhang, Vincent Ehreiser, Judith Huth, Khrystyna Shchurovska, Badr Kilani, Lisa Schweizer, Philipp E Geyer, Maximilian Zwiebel, Julia Novotny, Enzo Lüsebrink, Gemma Little, Martin Orban, Leo Nicolai, Shaza El Nemr, Anna Titova, Michael Spannagl, Jonas Kindberg, Alina L Evans, Orpheus Mach, Matthias Vogel, Steffen Tiedt, Steffen Ormanns, …,Tobias Petzold
Science. https://doi.org/10.1126/science.abo5044
2022
The impact of adjuvant therapy on outcome in UICC stage I pancreatic cancer
Guenther M, Boeck S, Heinemann V, Werner J, Engel J, Ormanns S.
Int J Cancer. https://doi.org/10.1002/ijc.34044
Bacterial Lipopolysaccharide as a Negative Predictor of Adjuvant Gemcitabine Efficacy in Pancreatic Cancer
Guenther M, Gil L, Surendran SA, Palm MA, Heinemann V, von Bergwelt-Baildon M, Mayerle J, Engel J, Werner J, Boeck S, Ormanns S.
JNCI Cancer Spectr. https://doi.org/10.1093/jncics/pkac039
2020
Bacterial lipopolysaccharide as negative predictor of gemcitabine efficacy in advanced pancreatic cancer – translational results from the AIO-PK0104 Phase 3 study
Guenther M, Haas M, Heinemann V, Kruger S, Westphalen CB, von Bergwelt-Baildon M, Mayerle J, Werner J, Kirchner T, Boeck S, Ormanns S.
Br J Cancer. https://doi.org/10.1038/s41416-020-01029-7