Publikationsliste
Ausgewählte Publikationen
2026
Neutrophil-Driven Trogocytosis in PDAC Liver Metastasis Restrains Immunosuppressive Macrophage Polarization and Limits Metastatic Progression
Larissa Belz, Dominic van den Heuvel, Badr Kilani, Alejandro Martinez-Navarro, Anastassia Akhalkatsi, Markus Joppich, Yinfeng Zhu, Qiongjie Ding, Jinlong Wan, Julia Stermann, Julia Winterhalter, Denise Messerer, Anna Titova, Sanjana Balaji, Santoshi Giri, Luke Eivers, Sebastian Widholz, Stefanie Bärthel, Elisabeth Raatz, Dieter Saur, Kirsten Lauber, Georg Beyer, Julia Mayerle, Steffen Ormanns, Michael Günther, Steffen Massberg, Hellen Ishikawa-Ankerhold, Konstantin Stark https://pubmed.ncbi.nlm.nih.gov/42102979/
IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases
Christina Plattner*, Gregor Sturm*, Anja A. Kühl*, Raja Atreya*, Sandro Carollo*, Raphael Gronauer, Dietmar Rieder, Michael Günther, Steffen Ormanns, Claudia Manzl, Stefan Wirtz, Asier Rabasco Meneghetti, Ahmed N. Hegazy, Jay V. Patankar, Zunamys I. Carrero, TRR241 IBDome Consortium, Markus F. Neurath, Jakob Nikolas Kather, Christoph Becker, Britta Siegmund, Zlatko Trajanoski https://pubmed.ncbi.nlm.nih.gov/40386420/
Multi‐omic profiling defines three distinct molecular subtypes of urothelial carcinoma with implications for precision therapy
Nils C. H. van Creij, Piotr Tymoszuk, Florian Handle, Andreas Seeber, Teresa Sellemond, Agnieszka Martowicz, Eva Comperat, Hamed Wafa, Steffen Ormanns, Michael Günther, Walther Parson, Maxim Noeparast, Frédéric R. Santer, José Daniel Subiela, Petros Grivas, Roger Li, Zoran Culig, Renate Pichler https://pubmed.ncbi.nlm.nih.gov/41804750/
Unveiling sex differences in pancreatic ductal adenocarcinoma: Current evidence and future directions
Rauschenberg S, Orgler-Gasche E, Karakas Zeybek D, Regel I, Löhr JM, Öhlund D, Günther M*, Aguilera Munoz L
Int J Oncol. https://doi.org/10.3892/ijo.2026.5848
*joint last author
Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer
Valentin Marteau, Niloofar Nemati*, Kristina Handler, Deeksha Raju, Alexander Kirchmair, Dietmar Rieder, Erika Kvalem Soto, Georgios Fotakis, Glenn De Lange, Sandro Carollo, Nina Boeck, Alessia Rossi, Sophia Daum, Alexandra Scheiber, Arno Amann, Andreas Seeber, Elisabeth Gasser, Steffen Ormanns, Michael Günther, …, Zlatko Trajanoski
Cancer Cell. https://doi.org/10.1016/j.ccell.2025.12.003
*joint first author
2025
Diagnostic approaches to cancer of unknown primary—the pathologist’s perspective
Guenther M, Brunner-Véber A, Ormanns S
Memo – Magazine of European Medical Oncology. https://link.springer.com/article/10.1007/s12254-025-01093-w
Ex vivo modelling of human colorectal cancer liver metastasis by normothermic machine perfusion
Manuel Trebo, Thomas Maurer, Felix J Krendl, Stefan Salcher, Agnieszka Martowicz, Theresa Hautz, Sieghart Sopper, Arno Amann, Benno Cardini, Lukas H Poelsler, Anna Mair, Julia Hofmann, Andras T Meszaros, Martin Hermann, Michael Günther, Steffen Ormanns, Zlatko Trajanoski, Stefan Schneeberger, Dominik Wolf, Rupert Oberhuber, Andreas Pircher
Mol Cancer. https://doi.org/10.1186/s12943-025-02430-7
Intratumoral bacterial abundance confers poor response to adjuvant gemcitabine in resected pancreatic cancer patients which is mitigated by postoperative antibiotics
Guenther M*, Surendran SA, Hauer N, Fahrenschon F, Arslan MD, Ormanns S.
Br J Cancer. https://doi.org/10.1038/s41416-025-03078-2
*joint first author
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer
Gilles Rademaker, Grace A Hernandez, Yurim Seo, Sumena Dahal, Lisa Miller-Phillips, Alexander L Li, Xianlu Laura Peng, Changfei Luan, Longhui Qiu, Maude A Liegeois, Bruce Wang, Kwun W Wen, Grace E Kim, Eric A Collisson, Stephan F Kruger, Stefan Boeck, Steffen Ormanns, Michael Guenther, Volker Heineman, Michael Haas, Mark R Looney, Jen Jen Yeh, Roberto Zoncu, Rushika M Perera
Nature. https://doi.org/10.1038/s41586-025-09017-8
FGFR1/3 Signaling as an Achilles‘ Heel of Phenotypic Diversity in Urothelial Carcinoma
Renate Pichler, Nils C H van Creij, Laura S Mertens, Francesco Del Giudice, Florestan Koll, Francesco Soria, José Daniel Subiela, Henning Plage, Piotr Tymoszuk, Roman Mayr, Gerald Klinglmair, Andreas Seeber, Martin Pichler, Michael Günther, Steffen Ormanns, Eva Compérat, Roger Li, Marco Moschini, Benjamin Pradére
Eur Urol Oncol. https://doi.org/10.1016/j.euo.2025.07.005
Multidimensional differences of right- and left-sided colorectal cancer and their impact on targeted therapies
Marwa Abdel Hamid, Lorenz M Pammer, Silvia Oberparleiter, Michael Günther, Arno Amann, Rebecca A Gruber, Anna Mair, Fabienne I Nocera, Steffen Ormanns, Kai Zimmer, Romana R Gerner, Florian Kocher, Samuel M Vorbach, Dominik Wolf, Jakob M Riedl, Florian Huemer, Andreas Seeber
NPJ Precis Oncol. https://doi.org/10.1038/s41698-025-00892-y
The Prognostic, Predictive and Clinicopathological Implications of KRT81/HNF1A- and GATA6-Based Transcriptional Subtyping in Pancreatic Cancer
Guenther M, Surendran SA, Steinke LM, Liou I, Palm MA, Heinemann V, Haas M, Boeck S, Ormanns S.
Biomolecules. https://doi.org/10.3390/biom15030426
2024
Prognostic and functional role of the nuclear export receptor 1 (XPO1) in gastrointestinal cancers: a potential novel target?
Viktorija Sokolova, Rebecca Gruber, Lorenz M Pammer, Florian Kocher, Eckhard Klieser, Arno Amann, Renate Pichler, Michael Günther, Steffen Ormanns, Daniel Neureiter, Andreas Seeber
Mol Biol Rep. https://doi.org/10.1007/s11033-024-10169-5
2023
TPX2 expression as a negative predictor of gemcitabine efficacy in pancreatic cancer
Guenther M, Surendran SA, Haas M, Heinemann V, von Bergwelt-Baildon M, Engel J, Werner J, Boeck S, Ormanns S.
Br J Cancer. https://doi.org/10.1038/s41416-023-02295-x
Immobility-associated thromboprotection is conserved across mammalian species from bear to human
Manuela Thienel, Johannes B Müller-Reif, Zhe Zhang, Vincent Ehreiser, Judith Huth, Khrystyna Shchurovska, Badr Kilani, Lisa Schweizer, Philipp E Geyer, Maximilian Zwiebel, Julia Novotny, Enzo Lüsebrink, Gemma Little, Martin Orban, Leo Nicolai, Shaza El Nemr, Anna Titova, Michael Spannagl, Jonas Kindberg, Alina L Evans, Orpheus Mach, Matthias Vogel, Steffen Tiedt, Steffen Ormanns, …,Tobias Petzold
Science. https://doi.org/10.1126/science.abo5044
2022
The impact of adjuvant therapy on outcome in UICC stage I pancreatic cancer
Guenther M, Boeck S, Heinemann V, Werner J, Engel J, Ormanns S.
Int J Cancer. https://doi.org/10.1002/ijc.34044
Bacterial Lipopolysaccharide as a Negative Predictor of Adjuvant Gemcitabine Efficacy in Pancreatic Cancer
Guenther M, Gil L, Surendran SA, Palm MA, Heinemann V, von Bergwelt-Baildon M, Mayerle J, Engel J, Werner J, Boeck S, Ormanns S.
JNCI Cancer Spectr. https://doi.org/10.1093/jncics/pkac039
2020
Bacterial lipopolysaccharide as negative predictor of gemcitabine efficacy in advanced pancreatic cancer – translational results from the AIO-PK0104 Phase 3 study
Guenther M, Haas M, Heinemann V, Kruger S, Westphalen CB, von Bergwelt-Baildon M, Mayerle J, Werner J, Kirchner T, Boeck S, Ormanns S.
Br J Cancer. https://doi.org/10.1038/s41416-020-01029-7